BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250806T050136EDT-8652gLElsI@132.216.98.100 DTSTAMP:20250806T090136Z DESCRIPTION: \n\nThe Killam Seminar Series presents 'Spreading confusion: p hysiological and pathological insights into spreading depolarizations and spreading depression” - in person and virtual event\n\nRegistration availa ble here. (virtual on the events platform)\n\nTo attend in person\, regist er here\n\nStreamed here via vimeo (you may send in your questions via thi s form)\n\nSpeaker: Peter Carlen\, Professor\n\nDept. of Medicine\, Physio logy and BME\, University of Toronto\, Canada\n\nSenior Scientist\, Krembi l Research Institute\, Toronto Western Hospital\, Canada\n\nAbstract: Wild er Penfield (1891–1976) was the director and world famous founder of epile psy surgery at the MNI\, who pioneered awake brain surgery for epilepsy. H e also originated the hypothesis of the centrencephalon (diencephalon and mesencephalon) as the origin of widespread epileptiform discharges and the most important area mediating consciousness. This spurred awareness\, con troversy and studies of the role of these structures in many processes inc luding epilepsy. However\, ‘out of sight\, out of mind’\, meaning that unt il now\, although extracranial and intracranial EEG are the gold standard measures for diagnosing epilepsy\, because brainstem recordings in humans are not possible\, and are difficult to do in animals\, little is known ab out brainstem seizures. Our lab took an interest in the concept of brainst em seizures based on fatal metabolic seizures in animal models not being a ssociated with cerebral EEG epileptiform abnormalities\, leading us to sea rch for seizures in the brainstem. Recently there has been a major effort to understand the pathogenesis of sudden\, unexpected death in epilepsy (S UDEP)\, which is considered to be due to cerebral seizures that invade the brainstem\, disrupting the brainstem cardiorespiratory centres leading to death. Clinical and experimental data will be presented ending with thoug hts on future clinical and investigative approaches for diagnosing and pre venting this devastating complication of epilepsy.\n\n\nSupported by the g enerosity of the Killam Trusts \, The Neuro’s Killam Seminar series hosts outstanding guest speakers whose research is of interest to the scientific community at The Neuro and ĢƵ.\n DTSTART:20220322T200000Z DTEND:20220322T210000Z LOCATION:Jeanne Timmins Amphitheatre\, Montreal Neurological Institute\, CA \, QC\, Montreal\, H3A 2B4\, 3801 rue University SUMMARY: Killam Seminar Series - Spreading Confusion: Physiological and Pat hological Insights into Spreading Depolarizations and Spreading Depression (in person and virtual event) URL:/neuro/channels/event/killam-seminar-series-spread ing-confusion-physiological-and-pathological-insights-spreading-338066 END:VEVENT END:VCALENDAR