BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250806T140455EDT-0819KN1IFU@132.216.98.100 DTSTAMP:20250806T180455Z DESCRIPTION:The Killam Seminar Series presents Molecular Logic of Synapse O rganization and Plasticity\n\nThe seminar will be taking placed in person at The Neuro (Jeanne Timmins Ampitheatre)\n\nTo attend in person\, registe r here.\n\nTo attend virtually\, register here.\n\nSpeaker: Tabrez Siddiqu i\, PhD\n\nUniversity of Manitoba\n\nAbstract: Connections between nerve c ells called synapses are the fundamental units of communication and inform ation processing in the brain. The accurate wiring of neurons through syna pses into neural networks or circuits is essential for brain organization. Neuronal networks are sculpted and refined throughout life by constant ad justment of the strength of synaptic communication by neuronal activity\, a process known as synaptic plasticity. Deficits in the development or pla sticity of synapses underlie various neuropsychiatric disorders\, includin g autism\, schizophrenia and intellectual disability. The Siddiqui lab res earch program comprises three major themes. One\, to assess how biochemica l switches control the activity of synapse organizing proteins\, how these switches act through their binding partners and how these processes are r egulated to correct impaired synaptic function in disease. Two\, to invest igate how synapse organizers regulate the specificity of neuronal circuit development and how defined circuits contribute to cognition and behaviour . Three\, to address how synapses are formed in the developing brain and m aintained in the mature brain and how microcircuits formed by synapses are refined to fine-tune information processing in the brain. Together\, thes e studies have generated fundamental new knowledge about neuronal circuit development and plasticity and enabled us to identify targets for therapeu tic intervention.\n\nBio: Dr. Tabrez Siddiqui trained as a biophysicist an d biochemist during his graduate studies at the Max Planck Institute for B iophysical Chemistry in Goettingen\, Germany. For postdoctoral work at the University of British Columbia\, he worked on mechanisms of neuronal syna pse development. His postdoctoral work has contributed immensely to unders tanding how glutamatergic synapses form and function in the brain. In 2014 \, Dr. Siddiqui joined the University of Manitoba where he is appointed in the department of physiology and pathophysiology. The Siddiqui lab is loc ated at the Klyesen Institute for Advanced Medicine\, where he is a princi pal investigator in the Neuroscience Research Program. The Siddiqui lab fo cuses on the roles of synaptic adhesion and scaffolding molecules in the d evelopment\, maintenance and plasticity of synapses and how these processe s can be regulated in health and disease. Dr. Siddiqui has nurtured a mult ifaceted research program encompassing the molecular\, systems\, and behav ioural branches of neuroscience. The Siddiqui lab has developed diverse ap proaches to address their questions\; protein chemistry\, glycobiology\, c ellular assays\, molecular genetics\, viral methods to manipulate neuronal circuits\, slice electrophysiology\, and animal behaviour.\n\n\nSupported by the generosity of the Killam Trusts \, The Neuro’s Killam Seminar seri es hosts outstanding guest speakers.\n DTSTART:20220531T200000Z DTEND:20220531T210000Z SUMMARY:Killam Seminar Series: Molecular Logic of Synapse Organization and Plasticity URL:/neuro/channels/event/killam-seminar-series-molecu lar-logic-synapse-organization-and-plasticity-339681 END:VEVENT END:VCALENDAR