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Improving research with more effective antibodies

Scientists demonstrate flaws in protein detection tools, and outline a solution

A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly.

Antibodies are used in laboratories and clinics to study proteins, which are the biomolecules that translate information from an organism鈥檚 genes into the structure, function, and regulation of its tissues and organs. Genetic mutations can cause protein imbalances or malfunctions, leading to human disease.

Classified as: ALS, Peter McPherson, antibodies, proteins, genetics, reproducibility, amyotrophic lateral sclerosis, genes
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Published on: 15 Oct 2019

Dr. Sandra Miller published an article in Current Trends in Immunology

TITLE:听Augmentation of cell numbers and function in the immune system by in vivo administration of North American (NA) ginseng (Panax Quinquefolium): Assessment in normal and cancer-bearing infant, juvenile, adult and elderly mice

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Published on: 7 Oct 2019

Reinhardt lab published new mechanisms in elastic fiber formation in the Proceedings of the National Academy of Sciences of the United States of America (PNAS)

Title: Fibulin-4 exerts a dual role in LTBP-4L鈥搈ediated matrix assembly and function

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Published on: 30 Sep 2019

Study shows the biological clock influences immune response efficiency

Montreal, September 23, 2019 鈥� According to a recent study published in Proceedings of the National Academy of Sciences of the United States of America, the biological clock influences immune response efficacy. Indeed, CD8 T cells, which are essential to fight infections and cancers, function very differently according to the time of day. The study was carried out by a team of researchers led by Nicolas Cermakian, PhD, of听the Douglas Research Centre, and Nathalie Labrecque, PhD, of the Maisonneuve-Rosemont Hospital Research Centre.

Classified as: 蘑菇短视频 Department of Psychiatry
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Published on: 23 Sep 2019

A Canadian First: Research Project will study blows to the head in University Football

蘑菇短视频 is participating in a new research project titled听T锚te premi猫re听(head first), led by the team of neuropsychologist听Dr. Louis De Beaumont, a researcher at the CIUSSS du Nord-de-l鈥櫭巐e-de-Montr茅al research centre and a professor in the Department of Surgery at Universit茅 de Montr茅al. The project will assess the brain鈥檚 capacities to sustain blows to the head during a full university football season.

Classified as: concussions
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Published on: 11 Sep 2019

How Salmonella tackles cellular defense mechanisms

Researchers uncover new protein that plays key role in bacterial infections

Bacterial infections represent a major public health concern, accounting for over 300 million foodborne illnesses and 60% of related fatalities globally.听Salmonella听alone is responsible for approximately 93.8 million illnesses and 155,000 deaths annually. Combined with the emergence of antibiotic-resistant听Salmonella听strains, it is critical that researchers improve our understanding of the molecular details governing bacterial infections.

Classified as: complex traits, salmonella
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Published on: 9 Sep 2019

Early life factors connected to suicide risk later in life

Researchers have long been interested in the question of whether a correlation exists between one鈥檚 early-life environment and suicide rates, with studies on the topic dating back to the 1980s. However, these studies have focused on individual countries or on only one or few risk factors. As a result, the lack of any meta-analysis of the data has made it difficult to draw any coherent conclusions.

Classified as: Douglas Mental Health University Institute, Psychiatry, suicide
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Published on: 9 Sep 2019

Amal Seffouh, a Postdoctoral Fellow in the Ortega lab, publishes her most recent work about the role of RbgA in the maturation of the 50S ribosomal subunit

Amal Seffouh, a Postdoctoral Fellow in the Ortega lab, publishes her most recent work about the role of RbgA in the maturation of the 50S ribosomal subunit.

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Published on: 9 Sep 2019

A new study shows that the hippocampus retains traces of negative and stressful experiences which are linked to depressive behaviours

Depression can be associated with behaviours such as social avoidance, that is, the refusal to interact with others for fear of being judged or criticized. Physicians and other mental health workers have noted that patients with depressive disorders exhibit cognitive symptoms, especially with regard to memory.

Classified as: hippocampus, 蘑菇短视频 Department of Psychiatry, memory
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Published on: 13 Aug 2019

Two 蘑菇短视频 professors lead new Stand Up to Cancer Canada Metastatic Breast Cancer Dream Team

Marc Miller, Member of Parliament (Ville-Marie鈥揕e Sud-Ouest鈥撁巐e-des-S艙urs, Quebec) and Parliamentary Secretary to the Minister of Crown-Indigenous Relations, on behalf of the Honourable Ginette Petitpas Taylor, Minister of Health, announced today at 蘑菇短视频 an investment of up to $6 million for a scientific task force of top researchers to develop new and improved approaches to cancer treatment and care. The funding will be distributed over four years to the new pan-Canadian program, the Stand Up to Cancer (SU2C) Canada Metastatic Breast Cancer Dream Team.

Classified as: stand up to cancer, Nahum Sonenberg, Michael Pollak, faculty of medicine, Oncology, breast cancer
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Published on: 12 Aug 2019

Surgery simulators are key to assessment of trainees

AI and virtual reality can determine neurosurgeon expertise with 90% accuracy

Machine learning-guided virtual reality simulators can help neurosurgeons develop the skills they need before they step in the operating room, according to a new study.

Classified as: MNI, rolando del maestro, neurosurgical stimulation, Artificial intelligence, Montreal Neurological Institute and Hospital (The Neuro), National Research Council of Canada, NeuroVR
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Published on: 2 Aug 2019

Study finds Nunavik Inuit are genetically unique

Variants found in this population may predispose to brain aneurysm

A new study has found that an Inuit population in Canada鈥檚 Arctic are genetically distinct from any known group, and certain genetic variants are correlated with brain aneurysm.

Classified as: aneurysm, Guy Rouleau, Sirui Zhou, Inuit, Canada, Nunavik, genetics
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Published on: 23 Jul 2019

Research team receives $6M to find new ways to treat metastatic breast cancer

Source: Terry Fox Research Institute

What is the best way to starve cancer cells? What role does obesity play in metastatic breast cancer and how does it affect the tumour microenvironment? Might combining a chemotherapeutic agent with a drug now used to treat diabetes be part of an effective therapy for metastatic breast cancer?

Classified as: breast cancer, Goodman Cancer Research Centre
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Published on: 4 Jul 2019

Aida Razi鈥檚 last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-蘑菇短视频

Aida Razi鈥檚 last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-蘑菇短视频.

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Read the paper at

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Published on: 4 Jul 2019

Researchers unlock mysteries of complex microRNA oncogenes

New research led by 蘑菇短视频鈥檚 Goodman Cancer Research Centre improves our understanding of microRNAs

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Classified as: cancer research, Goodman Cancer Research Centre, MicroRNA
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Published on: 27 Jun 2019

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